Civilization V when running in Wine has the following issues on my system with
nouveau:
all text is missing from game (in the menus, on the loading screens and in
mid-game)
when starting a game from the menu the upper menu bar that contains menu
options and icons is corrupted (terrain and units are rendered properly though)

The problem is not present:
- with the Nvidia binary drivers (340.76)
- when using the software renderer (LIBGL_ALWAYS_SOFTWARE=1)
- when starting the game with NV50_PROG_OPTIMIZE=0 or NV50_PROG_OPTIMIZE=1

See this screenshot for comparison:
http://imgur.com/pzpPgNL

I created a trace with apitrace and the problem is reproducible with that on my
system (uncompressed 366 MB):
https://drive.google.com/open?id=0B-tTbLKBl-tON09yaE14eEkwb28&authuser=0

Demo version is available on Steam (~4 GB download size):
http://store.steampowered.com/app/8930/

Fedora 22 32-bit
Mesa 10.6-branchpoint-684-g556dd4a
VGA compatible controller: NVIDIA Corporation G92 [GeForce GTS 250] (rev a2)
(prog-if 00 [VGA controller])
Kernel 4.0.5-300.fc22.i686+PAE
xorg-x11-server-Xorg-1.17.2-1.fc22.i686
libdrm-2.4.61-3.fc22.i686